Senomyx Reports 120% Up in Revenues in Q1 2010

Revenues were $7.7 million for the first quarter of 2010, compared to $3.5 million for the first quarter of 2009, an increase of 120%. As of March 31, 2010, the Company had cash, cash equivalents, and short term investments of approximately $54 million.

30 Apr 2010 --- Senomyx, Inc., a company focused on using proprietary taste receptor-based technologies to discover novel flavor ingredients for the food, beverage, and ingredient supply industries, provided a corporate update and reported financial results for the first quarter ended March 31, 2010. Revenues were $7.7 million for the first quarter of 2010, compared to $3.5 million for the first quarter of 2009, an increase of 120%. As of March 31, 2010, the Company had cash, cash equivalents, and short term investments of approximately $54 million.

"The beginning of 2010 has been very eventful for Senomyx," stated Kent Snyder, Chief Executive Officer of the Company. "We strengthened our balance sheet through our February financing and the receipt of nearly $10 million in milestone and license fee payments from collaborators. In addition, for the first time in Senomyx's history, three of our collaborators, Nestlé SA, Ajinomoto Co., Inc., and Firmenich SA, are conducting new market introductions of products that contain Senomyx flavor ingredients.

"We are pleased to announce that Firmenich, a global leader in providing ingredients and flavor systems to major consumer companies, has initiated commercial activities for Senomyx's extremely effective enhancer of the high-intensity sweetener sucralose," Snyder said. "Firmenich has exclusive worldwide rights to market our sucralose enhancer as either a stand-alone ingredient or as part of a flavor system in virtually all product categories.

"In addition, Nestlé, the world's largest food and beverage company, is continuing marketing activities with products that incorporate Senomyx's savory flavor ingredients in the Pacific Rim, Latin America, and Africa," Snyder stated. "Ajinomoto, a leading global manufacturer of food and culinary products, is engaged in initial commercial introductions of products that contain a Senomyx flavor ingredient in Asia and another key region.

"Senomyx is also making excellent progress with our Discovery & Development programs," Snyder noted. "We continue to be especially excited about the Company's success in developing sweet enhancers and bitter blockers, and the potential long-term value of these ingredients. Our identification of the first enhancers for fructose, our advances with new sucrose enhancers, and the anticipated accelerated timing for regulatory filings with our bitter blockers, are all significant accomplishments for Senomyx."

Also related to Senomyx's sweet enhancers, on April 26 Senomyx announced that the Company signed a term sheet with The Coca-Cola Company, the world's largest beverage company. This term sheet includes key commercial and financial terms for the potential continuation and expansion of a collaborative research program related to the discovery and commercialization of new flavor ingredients resulting from Senomyx's sweet taste technology. The two companies have been collaborating in the field of non-alcoholic beverages since April 2002.

Senomyx and The Coca-Cola Company have agreed to negotiate the definitive terms of a new collaborative agreement during the 60 day period after the signing of the term sheet, and during this period Senomyx will continue to receive funding at the same rate provided under the parties' original collaboration agreement.

Senomyx also has a collaboration with Firmenich that gives them exclusive worldwide rights for commercialization of certain Senomyx sweet enhancers in virtually all food product categories.

In addition to the Company's other progress, Senomyx increased its intellectual property portfolio during the past quarter. As of March 31, 2010, Senomyx is the owner or exclusive licensee of 189 issued patents and 383 pending patent applications related to proprietary taste receptor technologies in the U.S., Europe, and elsewhere. Technologies covered in the Company's patents include taste receptor sequences and functions, screening assays, new flavor ingredients, and product applications.

Senomyx management will expand on the significance of the Company's Discovery & Development advances and will provide comments regarding Senomyx's corporate collaborations during a conference call at 11:00 a.m. Eastern Time (8:00 a.m. Pacific Time). Details regarding access to the call and a subsequent archived recording are provided below.

Discovery & Development Program Updates:

Sweet Enhancer Program: The primary goal for this program is to identify flavor ingredients that allow a significant reduction of sweeteners in food and beverage products while maintaining the desired sweet taste. During the fourth quarter of 2009, Senomyx received a GRAS (Generally Recognized As Safe) regulatory designation for S6973, the Company's sucrose (table sugar) enhancer. The GRAS designation allows S6973, which enables up to 50% reduction of sugar in certain foods and beverages while maintaining the sweet taste of natural sugar, to be incorporated into specified products in the U.S. and in numerous other countries. During the first quarter of 2010, Senomyx was notified that the GRAS status for S6973 was extended to instant coffee and tea, as well as imitation dairy products such as non-dairy creamers and whiteners. Previous GRAS product categories for S6973 include baked goods, cereals, gum, condiments and relishes, confectioneries and frostings, frozen dairy offerings, fruit ices, gelatins and puddings, hard and soft candy, jams and jellies, milk products, and sauces.

Additional advances with the Sweet Enhancer Program include the identification of a new family of sucrose enhancers that allow for up to 40% reduction of sugar in preliminary taste tests. These alternative sucrose enhancers have distinct physical properties that may be advantageous for a broad range of beverages and other product applications that have specific requirements due to special packaging and storage conditions.

In March 2010, the Company announced the identification of the first Senomyx flavor ingredients that demonstrate a statistically significant amplification of the sweet taste of fructose, a key component of high fructose corn syrup, a widely used sweetener. High fructose corn syrup is the primary sweetener used in carbonated and certain other beverages, especially in North America. The new fructose enhancers will be optimized to increase their potency and evaluated further in taste tests.

Bitter Blocker Program: The primary goals of this program are to reduce or block bitter taste and to improve the overall taste characteristics of foods, beverages, and ingredients. Due to the considerable progress made since the beginning of the year, Senomyx now projects that the Company will be in position to submit regulatory applications for its S6821 bitter blocker during the fourth quarter of 2010. S0812, another promising bitter blocker, has met the Company's requirements for advancement into the development phase. Senomyx believes development activities with S0812 will conclude by year-end and regulatory filings will be made in early 2011.

Taste tests have demonstrated that S6821 and S0812, alone or in combination, can provide statistically significant reductions in the bitterness of a variety of product prototypes and food ingredients including tea, cocoa, menthol, various proteins, and the sweeteners Rebaudioside-A (a derivative of the stevia plant), Acesulfame potassium (Ace-K), and saccharine.

Salt Enhancer Program: The goal of the Salt Enhancer Program is to identify flavor ingredients that allow a significant reduction of sodium in foods and beverages yet maintain the salty taste desirable to consumers. Senomyx has identified enhancers of sodium chloride that are active in the Company's proprietary screening assays based on SNMX-29. In addition to conducting taste tests, the Company's scientists are using a number of chemistry and biology approaches to explore the role of SNMX-29 and other proteins that may contribute to the perception of salt taste, with the objective of demonstrating a taste proof-of-concept.

Cooling Flavor Program: The goal of the Cooling Flavor Program is to identify novel cooling flavors that do not have the limitations of currently available agents. Senomyx reported previously that it had identified cooling flavors from six different sample classes that demonstrated a taste proof-of-concept. In cooperation with Firmenich, the Company's partner for this program, three sample classes have been prioritized to be the focus of further optimization. Some of these new cooling flavors have displayed cooling properties that exceed those of commonly used agents.