24 Nov 2022 --- High dietary intakes of sulfites could be a safety concern for consumers of foodstuffs that contain the additives, EFSA’s experts concluded in their updated assessment of sulfur dioxide (E220) and sulfites (E221-228). Gaps in toxicity data meant the extent of certain adverse health effects could not be confirmed. Sulfite occurs naturally in the body as well as in foods such as apples, rice, onions, cabbage and beverages like wine.