Study Confirms No Cancer Link for Sucralose

23 Sep 2016 --- A comprehensive review of studies testing the safety and carcinogenicity of sucralose has confirmed that the artificial sweetener does not cause cancer and is safe to ingest. The new article has been published in Nutrition and Cancer: An International Journal.

“This latest review of sucralose studies should reassure those who choose sucralose, and can be particularly useful to scientists and healthcare professionals, who may be asked for information on low calorie sweetener safety,” says lead author of the study, Dr. Sir Colin Berry, Emeritus professor of pathology at the University of London.

Sir Berry and his research team carried out a review of studies assessing sucralose carcinogenicity potential and placed them in context of the types of studies relied upon by national and international regulatory agencies to make recommendations on the safety of new food ingredients. These studies are designed to maximize the possibility of detecting potentially adverse effects, and as such, adverse outcomes are expected to occur at some point.

Many of the studies looked at results of dosages which were hundreds to thousands of times greater than any reasonable level of consumption, including sucralose in quantities equivalent in sweetness to 74 to 495 pounds of sugar per day for an average adult weight (75kg). The Acceptable Daily Intake (ADI) for sucralose is 0 to 15 mg/kg body weight/day, set by the Joint Food and Agricultural Organization/World Health Organization Expert Committee on Food Additives.

In the studies investigated, even when sucralose levels were so much higher than the recommended ADI, no carcinogenic activity was demonstrated.

“Concerns are raised from time to time on what components of our lifestyle affect the rates of cancer,” continues Sir Berry. “Smoking and sunlight are on all our lists and obesity is beginning to be recognized as a major factor. So low calorie sweeteners, which are important to many in managing their weight, need to be examined carefully in terms of lifetime use.”

Funding for both the independent literature review, which formed the basis for the current paper, and the preparation of the manuscript, was provided by McNeil Nutritionals (creator of Splenda, since sold to Heartland Food Products). All study authors were employees of, or consultants to, McNeil Nutritionals at the time the manuscript was prepared. Some of the studies on the safety of sucralose reviewed in this study were also funded by the artificial sweetener industry.

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